Welcome to the Integrative Biology Project
The Integrative Biology project is bringing together an international consortium of leading biomedical and computing researchers to address two of the most important problems in clinical medicine today: understanding what causes heart failure and how cancer tumours develop and grow. Together these diseases account for about 60% of UK deaths.
Results from the Tulane whole ventricular model showing reentrant activity in the ventricles with transmembrane potential distribution on the anterior and posterior epicardial ventricle surfaces. RV and LV refer to right and left ventricles and arrows show the direction of wave propagation.
From DNA to whole organism modelling
Multi-scale models are the key to understanding the function of complex organs based on their genetic and cellular composition. The picture illustrates the different components and processes in the chain which must be modelled and integrated ranging from genetic information through cells and tissue to the behaviour of whole organs.
The Integrative Biology consortium brings together the original project partners - the Universities of Oxford, Nottingham, UCL, Leeds, Birmingham, Sheffield and Auckland plus CCLRC, EPSRC and IBM - and new partners who have since joined us including Tulane , Graz and Utrecht Universities, UCSD and UCLA.